American Journal of Emergency Medicine
Volume 25, Issue 8 , Pages 918-924, October 2007

An assessment of the association of bispectral index with 2 clinical sedation scales for monitoring depth of procedural sedation☆

  • Christopher S. Weaver, MD

      Affiliations

    • Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    • Corresponding Author InformationCorresponding author. Wishard Memorial Hospital, Indianapolis, IN 46202, USA. Tel.: +1 317 630 7276; fax: +1 317 6564216.
    • ,
  • William H. Hauter, MD

      Affiliations

    • Department of Anesthesiology, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • Cory E. Duncan, MD

      Affiliations

    • Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • Edward J. Brizendine, MS

      Affiliations

    • Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • William H. Cordell, MD

      Affiliations

    • Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

Received 13 October 2006; received in revised form 27 February 2007; accepted 27 February 2007.

Abstract 

Objective

We conducted a study to assess the correlation of bispectral index (BIS) to 2 clinical sedation scales.

Methods

This was a prospective, observational study. The BIS number was recorded at baseline and every 30 seconds. One investigator separately monitored the patients for depth of sedation using the Observer's Assessment of Alertness/Sedation and the Continuum of Depth of Sedation scales.

Results

During the 6-month period, 75 patients were enrolled. The Spearman correlation between the BIS and the Observer's Assessment of Alertness/Sedation was 0.59 (95% confidence interval [CI], 0.44-0.74). The Spearman correlation between the BIS and the Continuum of Depth of Sedation was 0.53 (95% CI, 0.36-0.70). The mean minimum BIS for patients without a complication was 70 (SD, 15.9) compared with 68 (SD, 12.9) for patients with a complication (difference = 2; 95% CI, −7-11).

Conclusions

Our study demonstrated moderate correlation between BIS and the 2 clinical sedation scales. The correlation is not strong enough to be used reliably in a clinical setting. The mean minimum BIS scores were not significantly different for those with sedation complications vs those without complications.

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☆ The poster presentation for this was made in May 2004 at the Society for Academic Emergency Medicine Annual Meeting in Orlando, Fla.

PII: S0735-6757(07)00184-2

doi:10.1016/j.ajem.2007.02.042

American Journal of Emergency Medicine
Volume 25, Issue 8 , Pages 918-924, October 2007

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