Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study
Received 30 July 2007; accepted 13 September 2007.
Abstract
Background
This study investigates the short-term and long-term effects of thymosin alpha 1 (Talpha1) on reimplantation of avulsed teeth.
Methods and Material
Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1. The teeth were reimplanted after treatment with Talpha1 or saline. Patients were monitored for both short-term and long-term parameters.
Results
The thymosin group demonstrated a lower interferon, tumor necrosis factor α and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05). The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.
Conclusion
The use of Talpha1 has both short-term and long-term beneficial effects during reimplantation of avulsed teeth.
aJinhua Dentistry, Kowloon, Hong Kong, People’s Republic of China
bLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
cState Key Laboratory of Oral Diseases, West China Stomatology College, Sichuan University, Chengdu, People’s Republic of China
Corresponding author. State Key Laboratory of Oral Diseases Engineering, Ministry of Education, West China of Stomatology College, Sichuan University, Chengdu 610041, People's Republic of China. Tel.: +86 852 2345 7671; fax: +86 852 3176 7247.
ABSTRACT