Abstract
Background
Carbon monoxide (CO) is one of the major causes of poisoning worldwide. We aimed to
investigate the efficacy of the continuous positive airway pressure (CPAP) use in
CO poisoning.
Methods
After CO poisoning, one group of patients was treated with a non-rebreather mask (NRB)
and another group using the CPAP mode of mechanical ventilation (CPAP). All patients
received at least 90 minute treatment. The carboxyhemoglobin saturation (SpCO) levels
of all patients were measured from the fingertips with a portable CO-oximeter at 0,
30, 60 and 90 min. The rates of changes in the serially measured SpCO values were
obtained using the Wilcoxon signed-rank test.
Results
A total of 45 patients (24 in NRB and 21 in CPAP group) completed the study. The median
initial SpCO levels were 24% (21−33) in NRB group, 25% (21−32) in CPAP group, with
no statistically significant difference (p 0.323). At the 30th, 60th, and 90th minutes of treatment, significantly lower values
were obtained from CPAP than NRB (p < 0.001). The COHb half-life was decreased significantly
by CPAP [105(70–190) vs 45(30−120), p < 0.001]. In CPAP group, the fastest decline
in the SpCO level was observed for the interval of 0–30 min [Median difference: 8(3–14),
p < 0.001].
Conclusions
CPAP lowered the amount of CO in the blood faster than the mask; therefore, it may
be effective in the treatment of CO poisoning.
Keywords
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Article Info
Publication History
Published online: April 17, 2020
Accepted:
April 13,
2020
Received in revised form:
April 13,
2020
Received:
February 28,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
