Abstract
Objective
Previous studies show that serum fibrinogen levels are established risk factors for
coronary artery disease (CAD) and that serum albumin levels are of a higher specificity
and sensitivity in ST-elevation myocardial infarction (STEMI). In this study, we sought
to evaluate the association between fibrinogen to albumin ratio (FAR) and the extent
and severity of CAD evaluated by TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass
Surgery for the Treatment of Narrowed Arteries (SYNTAX) Score (SS) in patients with
STEMI.
Methods
A total of 278 patients with STEMI were included in the study. FAR was calculated
using specified variables. The extent and severity of CAD were evaluated using the
SS. The patients were divided into low- (SS < 22) and high- (SS ≥ 22) risk groups. A Spearman rank correlation coefficient analysis was used for the
relationship between FAR and SS. The cutoff points for sensitivity and specificity
of FAR in predicting SS were estimated by performing a receiver operator characteristic
curve analysis.
Results
There were significant differences in the mean age (P = .016), admission serum albumin (P = .041), serum fibrinogen (P < .001), FAR (P < .001), and SS risk groups. Positive correlation was detected between FAR and SS (r = 0.458, P < .001). A cutoff level of >87 FAR predicted SS (sensitivity, 70%; specificity, 70%), and an area under the curve
of 0.758 serum fibrinogen and albumin level was an independent predictor for SS in
patients with STEMI (b = 0.039; 95% confidence interval, 0.016-0.062; P = .001 and b = −6.906; 95% confidence interval, −12.284 to −1.527; P = .013, respectively).
Conclusion
In the present study, we showed that FAR is significantly related to SS in predicting
the severity of CAD in patients with STEMI.
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Article Info
Publication History
Published online: March 03, 2016
Accepted:
March 1,
2016
Received in revised form:
February 23,
2016
Received:
February 2,
2016
Footnotes
☆Conflict interest and funding: The authors of this study declare that there is no conflict of interest regarding the publication of this manuscript. There were no external funding sources for this clinical study.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
