Abstract
Purpose
Ischemic contracture compromises the hemodynamic effectiveness of cardiopulmonary
resuscitation (CPR) and resuscitability from cardiac arrest. In a pig model of cardiac
arrest, 2,3-butanedione monoxime (BDM) attenuated ischemic contracture. We investigated
the effects of different doses of BDM to determine whether increasing the dose of
BDM could improve the hemodynamic effectiveness of CPR further, thus ultimately improving
resuscitability.
Methods
After 16 minutes of untreated ventricular fibrillation and 8 minutes of basic life support, 36 pigs were divided randomly into 3 groups that received
50 mg/kg (low-dose group) of BDM, 100 mg/kg (high-dose group) of BDM, or an equivalent volume of saline (control group)
during advanced cardiovascular life support.
Results
During advanced cardiovascular life support, the control group showed an increase
in left ventricular (LV) wall thickness and a decrease in LV chamber area. In contrast,
the BDM-treated groups showed a decrease in the LV wall thickness and an increase
in the LV chamber area in a dose-dependent fashion. Mixed-model analyses of the LV
wall thickness and LV chamber area revealed significant group effects and group-time
interactions. Central venous oxygen saturation at 3 minutes after the drug administration was 21.6% (18.4-31.9), 39.2% (28.8-53.7), and
54.0% (47.5-69.4) in the control, low-dose, and high-dose groups, respectively (P < .001). Sustained restoration of spontaneous circulation was attained in 7 (58.3%),
10 (83.3%), and 12 animals (100%) in the control, low-dose, and high-dose groups,
respectively (P = .046).
Conclusion
2,3-Butanedione monoxime administered during CPR attenuated ischemic contracture and
improved the resuscitability in a dose-dependent fashion.
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Article Info
Publication History
Published online: March 11, 2016
Accepted:
March 7,
2016
Received in revised form:
March 7,
2016
Received:
January 11,
2016
Footnotes
☆Funding sources/disclosures: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2015R1D1A1A09057248 ). The funder had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
