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Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies

Published:October 13, 2021DOI:https://doi.org/10.1016/j.ajem.2021.07.062

      Abstract

      Introduction

      It is not well established to use vitamin D supplementation for migraine, and this meta-analysis aims to explore the efficacy of vitamin D for migraine patients.

      Methods

      PubMed, EMbase, Web of science, EBSCO and Cochrane library databases were systematically searched up to May 2021, and we included randomized controlled trials (RCTs) exploring the effect of vitamin D for migraine patients.

      Results

      Six RCTs and 301 patients were included in the meta-analysis. Compared with control group in migraine patients, vitamin D supplementation could remarkably decrease headache attacks per month (MD = −2.74; 95% CI = −3.82 to −1.67; P < 0.00001), headache days per month (MD = −1.56; 95% CI = −2.44 to −0.68; P = 0.0005) and MIDAS score (MD = −5.72; 95% CI = −10.90 to −0.54; P = 0.03), but demonstrated no obvious influence on attack duration (MD = −2.20; 95% CI = −7.38 to 2.97; P = 0.40) or headache severity (MD = −0.56; 95% CI = −1.18 to 0.06; P = 0.08).

      Conclusions

      Vitamin D supplementation provided additional benefits to treat migraine.

      Keywords

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      References

        • Steiner T.J.
        • Stovner L.J.
        • Vos T.
        • Jensen R.
        • Katsarava Z.
        Migraine is first cause of disability in under 50s: will health politicians now take notice?.
        J. Headache Pain. 2018; 19: 17
        • Steiner T.J.
        • Stovner L.J.
        • Vos T.
        GBD 2015: migraine is the third cause of disability in under 50s.
        J. Headache Pain. 2016; 17: 104
        • Stovner L.
        • Hagen K.
        • Jensen R.
        • Katsarava Z.
        • Lipton R.
        • Scher A.
        • et al.
        The global burden of headache: a documentation of headache prevalence and disability worldwide.
        Cephalalgia. 2007; 27: 193-210
        • Vetvik K.G.
        • MacGregor E.A.
        Sex differences in the epidemiology, clinical features, and pathophysiology of migraine.
        Lancet Neurol. 2017; 16: 76-87
        • Adams J.
        • Barbery G.
        • Lui C.W.
        Complementary and alternative medicine use for headache and migraine: a critical review of the literature.
        Headache. 2013; 53: 459-473
        • Hepp Z.
        • Bloudek L.M.
        • Varon S.F.
        Systematic review of migraine prophylaxis adherence and persistence.
        J. Manag. Care Pharm.: JMCP. 2014; 20: 22-33
        • Blumenfeld A.M.
        • Bloudek L.M.
        • Becker W.J.
        • Buse D.C.
        • Varon S.F.
        • Maglinte G.A.
        • et al.
        Patterns of use and reasons for discontinuation of prophylactic medications for episodic migraine and chronic migraine: results from the second international burden of migraine study (IBMS-II).
        Headache. 2013; 53: 644-655
        • Ghorbani Z.
        • Togha M.
        • Rafiee P.
        • Ahmadi Z.S.
        • Rasekh Magham R.
        • Haghighi S.
        • et al.
        Vitamin D in migraine headache: a comprehensive review on literature.
        Neurol. Sci. 2019; 40: 2459-2477
        • Gazerani P.
        • Fuglsang R.
        • Pedersen J.G.
        • Sørensen J.
        • Kjeldsen J.L.
        • Yassin H.
        • et al.
        A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine.
        Curr. Med. Res. Opin. 2019; 35: 715-723
        • Yilmaz R.
        • Salli A.
        • Cingoz H.T.
        • Kucuksen S.
        • Ugurlu H.
        Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency.
        Int. J. Rheum. Dis. 2016; 19: 1255-1262
        • Mottaghi T.
        • Askari G.
        • Khorvash F.
        • Maracy M.R.
        Effect of vitamin D supplementation on symptoms and C-reactive protein in migraine patients.
        J. Res. Med. Sci. 2015; 20: 477-482
        • Knutsen K.V.
        • Madar A.A.
        • Brekke M.
        • Meyer H.E.
        • Natvig B.
        • Mdala I.
        • et al.
        Effect of vitamin D on musculoskeletal pain and headache: a randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway.
        Pain. 2014; 155: 2591-2598
        • Ghorbani Z.
        • Togha M.
        • Rafiee P.
        • Ahmadi Z.S.
        • Rasekh Magham R.
        • Djalali M.
        • Shahemi S.
        • Martami F.
        • Zareei M.
        • Razeghi Jahromi S.
        • Ariyanfar S.
        • Mahmoudi M.
        Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
        Neurol. Sci. 2020 May; 41: 1183-1192
        • Ghorbani Z.
        • Rafiee P.
        • Fotouhi A.
        • Haghighi S.
        • Rasekh Magham R.
        • Ahmadi Z.S.
        • et al.
        The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial.
        J. Headache Pain. 2020; 21: 22
        • Fallah R.
        • Sarraf Yazd S.
        • Sohrevardi S.M.
        Efficacy of Topiramate alone and Topiramate plus vitamin D3 in the prophylaxis of pediatric migraine: a randomized clinical trial.
        Iran. J. Child Neurol. 2020; 14: 77-86
        • Moher D.
        • Liberati A.
        • Tetzlaff J.
        • Altman D.G.
        • P. Group
        Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
        Bmj. 2009; 339: b2535
        • HigginsJPT G.
        Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. 0 [Updated March 2011].
        The Cochrane Collaboration, 2011
        • Jadad A.R.
        • Moore R.A.
        • Carroll D.
        • Jenkinson C.
        • Reynolds D.J.M.
        • Gavaghan D.J.
        • et al.
        Assessing the quality of reports of randomized clinical trials: is blinding necessary?.
        Control. Clin. Trials. 1996; 17: 1-12
        • Kjaergard L.L.
        • Villumsen J.
        • Gluud C.
        Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses.
        Ann. Intern. Med. 2001; 135: 982-989
        • Higgins J.P.
        • Thompson S.G.
        Quantifying heterogeneity in a meta-analysis.
        Stat. Med. 2002; 21: 1539-1558
        • Mottaghi T.
        • Askari G.
        • Khorvash F.
        • Maracy M.R.
        Effect of vitamin D supplementation on symptoms and C-reactive protein in migraine patients.
        J. Res. Med. Sci. 2015; 20: 477-482
        • Buettner C.
        • Nir R.-R.
        • Bertisch S.M.
        • Bernstein C.
        • Schain A.
        • Mittleman M.A.
        • et al.
        Simvastatin and vitamin D for migraine prevention: a randomized, controlled trial.
        Ann. Neurol. 2015; 78: 970-981
        • Ghorbani Z.
        • Togha M.
        • Rafiee P.
        • Ahmadi Z.S.
        • Rasekh Magham R.
        • Haghighi S.
        • et al.
        Vitamin D in migraine headache: a comprehensive review on literature.
        Neurol. Sci. 2019; 40: 2459-2477
        • Togha M.
        • Razeghi Jahromi S.
        • Ghorbani Z.
        • Martami F.
        • Seifishahpar M.
        Serum vitamin D status in a Group of Migraine Patients Compared with Healthy Controls: a case–control study.
        Headache. 2018; 58: 1530-1540
        • Dodick D.W.
        A phase-by-phase review of migraine pathophysiology.
        Headache. 2018; 58: 4-16
        • Malhotra R.
        Understanding migraine: potential role of neurogenic inflammation.
        Ann. Indian Acad. Neurol. 2016; 19: 175-182
        • Iyengar S.
        • Johnson K.W.
        • Ossipov M.H.
        • Aurora S.K.
        CGRP and the trigeminal system in migraine.
        Headache. 2019; 59: 659-681
        • Edvinsson L.
        The trigeminovascular pathway: role of CGRP and CGRP receptors in migraine.
        Headache. 2017; 57: 47-55
        • Lukacs M.
        • Tajti J.
        • Fulop F.
        • Toldi J.
        • Edvinsson L.
        • Vecsei L.
        Migraine, Neurogenic inflammation, drug development - pharmacochemical aspects.
        Curr. Med. Chem. 2017; 24: 3649-3665
        • Ramachandran R.
        Neurogenic inflammation and its role in migraine.
        Semin. Immunopathol. 2018; 40: 301-314
        • Olesen J.
        The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache.
        Pharmacol. Ther. 2008; 120: 157-171
        • Hathcock J.N.
        • Shao A.
        • Vieth R.
        • Heaney R.
        Risk assessment for vitamin D.
        Am. J. Clin. Nutr. 2007; 85: 6-18