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Abstract
Angiotensin-converting enzyme inhibitors are a widely used antihypertensive modality.
While they have a favorable side effect profile, there is a .1% to .2% incidence of
potentially life threatening angioedema. The edema usually presents in the head and
neck, especially the face, lips, tongue, and glottis. Patients may initially be treated
with standard antiallergic therapy; however, the situation may dictate a more aggressive
therapeutic approach. The authors present the case of a patient who presented with
angioedema 18 times over a 3-year period to qualified emergency physicians before
the correct diagnosis of angiotensin-converting enzyme inhibitor-induced angioedema
was made. Despite recent literature on the subject, there appears to be a lack of
familiarization among emergency department physicians regarding this relatively common
adverse effect.
Keywords
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References
- NCHS Advance Data, Vital and Health Statistics of the National Center for Health Statistics. Department of Health and Human Services, Washington, DCOctober 8, 1982 (No. 84) ed 4.
- Angiotensin-converting enzyme inhibitors.Hypertension. 1989; 13: I125-I130
- Angiotensin-converting enzyme inhibitors and the allergist.Ann Allergy. 1990; 64: 503-506
- Clinical characteristics of angiotensin-converting enzyme inhibitor induced angioedema.Ann Emerg Med. 1991; 20: 555-558
- Clinical profile of angioedema associated with angiotensin-converting enzyme inhibition.JAMA. 1988; 260: 967-970
- Hereditary angioneurotic edema.J Allergy Clin Immunol. 1962; 33: 316-319
- Angioedema related to angiotensin-converting enzyme inhibitors.Otolaryngol Head Neck Surg. 1990; 102: 727
- Severe angioedema related to ACE inhibitors in patients with a history of idiopathic angioedema.JAMA. 1990; 264: 1287-1289
- Urticaria, angioedema and mediator release in humans in response to physical environmental stimuli.in: ed 4. Fed Proc. 36. 1977: 1736-1741
- Effects of intradermal bradykinin after inhibition of angiotensin converting enzyme.Br Med J. 1987; 294: 119-120
- Studies of the mechanism of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema: The effect of an ACE inhibitor on cutaneous responses to bradykinin, codeine, and histamine.J Allergy Clin Immunol. 1990; 85: 856-858
- Robbins Pathologic Basis of Disease. Saunders, Philadelphia, PA1989: 54-57 ed 4.
- Conversion of angiotensin I to angiotensin II.Am J Med. 1976; 60: 749-759
- ‘Kinases’ in bradykinin, kallikiden, and kallikrein.in: Handbook of Experimental Pharmacology. vol 25. Springer-Verlag, Berlin1979: 427-487
- Pharmacology of bradykinin and related kinins.Pharmacol Rev. 1980; 32: 1-46
- Angioedema from ACE inhibitors: A cause of upper airway obstruction.Laryngoscope. 1990; 100: 1156-1160
- Severe angioedema after long term use of an ACE inhibitor.Ann Intern Med. 1990; 112: 312-313
Article Info
Publication History
Accepted:
May 20,
1992
Received:
March 9,
1992
Identification
Copyright
© 1992 Published by Elsevier Inc.