An unusual case of dipropylene glycol toxicity

      The recent case report published by LoVecchio et al describing renal failure with cortical necrosis and polyneuropathy after the ingestion of a dipropylene glycol (DPG) containing product highlights several of the clinically relevant limitations to timely diagnosis of the toxic alcohol-poisoned patient. This is particularly apparent when patients present late in the course of illness. Unfortunately, most health care facilities have limited, if any, capabilities to measure the toxic alcohol and their respective acid metabolites. This case describes previously unreported clinical findings after DPG exposure including delayed onset renal failure with evidence of cortical necrosis and progressive peripheral axonopathy that was persistent at 6-month follow-up.
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      Linked Article

      • Massive dipropylene glycol toxicity is very similar in presentation to cases of diethylene glycol toxicity
        The American Journal of Emergency MedicineVol. 27Issue 1
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          We agree with the comments by Dr Marraffa that our patient with dipropylene glycol (DPG) toxicity is very similar is presentation to cases of diethylene glycol (DEG) toxicity. We agree that DEG toxicity should be in the differential diagnosis in this patient and others with acute renal failure due to cortical necrosis and demyelinating sensorimotor peripheral polyneuropathy. We were somewhat surprised as to the toxicity that had arisen from DPG ingestion in our patient. We feel that in animal studies with massive ingestions, DPG presents a similar scenario.
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