Abstract
The aim of this study is to investigate the effects of electroacupuncturing (EA) zusanli
points on levels of basic hemodynamics, lactate, and cytokines in dogs with hemorrhagic
shock. Thirty healthy dogs were randomly divided into 5 groups: sham hemorrhagic shocked
group, hemorrhagic shocked group, EA group, nonacupuncturing group, and EA after vagotomy
group. Zusanli points were electroacupunctured with constant voltage (10-15 V, 30
Hz) for 30 minutes immediately after the shock models were established. Before the
stimulation, a blood pressure transducer was implanted into the right femoral artery
for continuous recording of mean arterial pressure (MAP), and a 5F Swan-Ganz pediatric
catheter was implanted into the pulmonary artery. The levels of serum tumor necrosis
factor α (TNF-α) in the femoral artery were detected at 0, 120, and 180 minutes after hemorrhage.
The levels of serum lactate in the femoral artery were detected before hemorrhage
(−45 minutes), at 0 minute, and at 180 minutes. In the hemorrhagic shocked group,
the levels of MAP, cardiac output, cardiac index, central venous pressure, and pulmonary
arterial wedge pressure decreased significantly; at the same time, the levels of serum
TNF-α and serum lactate increased significantly. There were no differences between these
groups and the hemorrhagic group, but they were different from the sham hemorrhagic
shocked group. In the EA group, the levels of MAP, cardiac output, cardiac index,
central venous pressure, and pulmonary arterial wedge pressure gradually increased,
but the content of serum TNF-α and lactate obviously decreased. The results suggested that EA zusanli points produce
a protective effect on hemorrhagic shock in dogs.
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Article Info
Publication History
Published online: October 11, 2010
Accepted:
July 11,
2010
Received in revised form:
July 10,
2010
Received:
February 4,
2010
Footnotes
☆This work was supported by the National Natural Science Foundation of China (grant 200630672727), the Natural Science Foundation of Hubei Province of China (grant 2004ABA161), and the Tackle Key Problems in Science and Technology of Hubei Province of China (grant 2007AA301B46).
Identification
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