Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock

Simon Bourcier; Nicolas Mongardon; Fabrice Daviaud; Laurence Moachon; Marc-Antoine Arnould; Franck Perruche; Frédéric Pène; Alain Cariou

doi:10.1016/j.ajem.2012.05.002

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Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock

Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

¹SB and NM contributed equally to this work and are both first authors.

Nicolas Mongardon, MD¹^,

Fabrice Daviaud, MD

Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France

Laurence Moachon, MD

Regional Center of Pharmacovigilance, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France

Marc-Antoine Arnould, MD

Department of Cardiology, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France

Franck Perruche, MD

Emergency Department, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

Frédéric Pène, MD, PhD

Alain Cariou, MD, PhD

Medical Intensive Care Unit, Cochin Hospital, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 15 rue de l'Ecole de Médecine, 75006 Paris, France

DOI: http://dx.doi.org/10.1016/j.ajem.2012.05.002

Article Info

Shock is a common reason for medical intensive care unit admission, with septic and cardiogenic accounting for most of the etiologies. However, the potential severity of adverse side effects of drugs indicates that any medication should be carefully scrutinized for potential pharmacokinetic and pharmacodynamic interactions that may result. We herein report the case of a life-threatening shock mimicking successively anaphylactic, cardiogenic, and septic shock, which was finally related to disulfiram ethanol reaction.

Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock

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