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Angioedema after the first dose of metformin

Published:February 04, 2013DOI:https://doi.org/10.1016/j.ajem.2012.10.021
      Metformin is a biguanide group antihyperglycemic agent that reduces the basal and postprandial glucose level and increases glucose tolerance in patients with type II diabetes mellitus. The rarely observed side effects are nausea, vomiting, diarrhea, and abdominal pain. In some hypersensitive patients, mild erythema has been reported. In this case report, angioedema developed immediately after 1 dose of metformin usage.
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      References

        • Stumvoll M.
        • et al.
        Metabolic effects of metformin in non–insulin-dependent diabetes mellitus.
        N Engl J Med. 1995; 333: 550-554
        • Wiernsperger N.F.
        • Bailey C.J.
        The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms.
        Drugs. 1999; 58 (discussion 75–82): 31-39
        • Wu M.S.
        • et al.
        Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients.
        Diabetes Care. 1990; 13: 1-8
        • Fonseca V.
        • et al.
        Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial.
        JAMA. 2000; 283: 1695-1702
        • Di Cicco R.A.
        • et al.
        Rosiglitazone does not alter the pharmacokinetics of metformin.
        J Clin Pharmacol. 2000; 40: 1280-1285
        • Ben Salem C.
        • et al.
        Rare case of metformin-induced leukocytoclastic vasculitis.
        Ann Pharmacother. 2006; 40: 1685-1687
        • Czarnowicki T.
        • et al.
        Metformin-induced leukocytoclastic vasculitis: a case report.
        Am J Clin Dermatol. 2012; 13: 61-63
        • Koca R.
        • et al.
        Psoriasiform drug eruption associated with metformin hydrochloride: a case report.
        Dermatol Online J. 2003; 9: 11
        • Shore S.A.
        • Williams E.S.
        • Zhu M.
        No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
        J Appl Physiol. 2008; 105: 1127-1133