Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey
Correspondence
Corresponding author. Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey. Tel.: +90 216 632 1818-(1426), +90 533 495 7520 (Mobile).
Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey
Correspondence
Corresponding author. Department of Emergency Medicine, Umraniye Training and Research Hospital, Istanbul, Turkey. Tel.: +90 216 632 1818-(1426), +90 533 495 7520 (Mobile).
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Figures
Fig. 1
Eye divergence before ILE treatment in case 2.
Fig. 2
Urine color change after ILE treatment in case 3.
Fig. 3
a, Anterior-posterior chest radiography image 2 days after the ILE treatment, in case 4. b, Control anterior-posterior chest radiography 2 days after the first radiography.
Fig. 4
a-d, Thorax computed tomographic images of fat infiltration in case 4, 2 days after the ILE treatment.
Abstract
Intravenous lipid emulsion (ILE) is a lifesaving treatment of lipophilic drug intoxications. Not only does ILE have demonstrable efficacy as an antidote to local anesthetic toxicity, it is also effective in lipophilic drug intoxications.
Our case series involved 10 patients with ingestion of different types of lipophilic drugs. Intravenous lipid emulsion treatment improved Glasgow Coma Scale or blood pressure and pulse rate or both according to the drug type. Complications were observed in 2 patients (minimal change pancreatitis and probable ILE treatment–related fat infiltration in lungs).
In our case series, ILE was used for different lipophilic drug intoxications to improve cardiovascular and neurologic symptoms. According to the results, it was found that ILE treatment is a lifesaving agent in lipophilic drug intoxications and it can be used in unconscious patients who have cardiac and/or neurologic symptoms but no history of a specific drug ingestion.
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