Possible association between Takotsubo cardiomyopathy, sepsis, and diabetes mellitus: a still open question

Fabio Fabbian; Alfredo De Giorgi; Ruana Tiseo; Benedetta Boari; Raffaella Salmi; Fulvia Signani; Beatrice Zucchi; Roberto Manfredini

doi:10.1016/j.ajem.2015.07.042

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Possible association between Takotsubo cardiomyopathy, sepsis, and diabetes mellitus: a still open question

Fabio Fabbian, MD

Alfredo De Giorgi, MD

Ruana Tiseo, MD

Benedetta Boari, MD

University of Ferrara, School of Medicine, Ferrara, Italy

Raffaella Salmi, MD

Ferrara General Hospital, Ferrara, Italy

Fulvia Signani, PsyD

University of Ferrara, Ferrara, Italy

Beatrice Zucchi, PedD

Roberto Manfredini, MD

University of Ferrara, School of Medicine, Ferrara, Italy

DOI: http://dx.doi.org/10.1016/j.ajem.2015.07.042

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We appreciated the comments by Dr Madias [1], raising some interesting key points. On one hand, we quite agree that emotional and physical stressors are not strictly separated entities and, in most cases, may overlap as triggering factors of Takotsubo cardiomyopathy (TTC). However, this definition is widely used [2,3]. The association between diabetes mellitus (DM) and TTC has been matter of several investigations. Pelliccia et al [3], evaluating a series of 19 studies (1109 patients), after a contact with corresponding authors, asked to provide additional quantitative details, concluded that patients with TTC have a relevant prevalence of cardiovascular risk factors and associated comorbidities.

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Possible association between Takotsubo cardiomyopathy, sepsis, and diabetes mellitus: a still open question

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