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Human Carbon Monoxide Factory

Karin Howe
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Karin Howe
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Affiliations

  • Division of Emergency Medicine, Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL, USA 62794-9638
  • Department of Emergency Medicine, Memorial Medical Center, 701 North First St, Springfield, IL 62781
, DO
,
David Griffen
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David Griffen
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Affiliations

  • Division of Emergency Medicine, Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL, USA 62794-9638
  • Department of Emergency Medicine, Memorial Medical Center, 701 North First St, Springfield, IL 62781

Correspondence

  • Corresponding author at: Emergency Medicine, Southern Illinois University School of Medicine, 701 North First Street, Springfield, IL, USA 62781. Tel.: +1 217 545 7409; fax: +1 217 545 2711.
, MD, PhDcorrespondence
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David Griffen
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Affiliations

  • Division of Emergency Medicine, Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL, USA 62794-9638
  • Department of Emergency Medicine, Memorial Medical Center, 701 North First St, Springfield, IL 62781

Correspondence

  • Corresponding author at: Emergency Medicine, Southern Illinois University School of Medicine, 701 North First Street, Springfield, IL, USA 62781. Tel.: +1 217 545 7409; fax: +1 217 545 2711.
,
Cassie Jaeger
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Cassie Jaeger
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Affiliations

  • Southern Illinois University, School of Medicine, Center for Clinical Research, 201 East Madison, PO Box 19664, Springfield, IL, USA 62794-9664
, PhD
DOI: http://dx.doi.org/10.1016/j.ajem.2016.04.008

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Figures

Figure 1

Carboxyhemoglobin level post arrival time to Emergency Department. COHb level remained elevated up to 12 hours after arrival despite being on high flow oxygen therapy.

Methylene chloride is a common occupational exposure. A metabolic product of methylene chloride is carbon monoxide (CO) and toxicity can lead to increased carboxyhemoglobin (COHb) levels. The half-life of COHb is prolonged in methylene chloride toxicity as the conversion to CO can last several hours beyond the exposure. In addition, methylene chloride can be stored in tissues, particularly adipose tissue, and converted to CO over time. The following case demonstrates that patients exposed to methylene chloride can essentially become CO factories with the production of CO within the body continuing long after exposure to the toxin.

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© 2016 Published by Elsevier Inc.
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