Abstract
Introduction
Reperfusion therapies play an important role in early-period treatment for patients
presenting to the emergency department due to stroke. However, the ischemia-reperfusion
injury that may occur with reperfusion must then be considered. The purpose of this
study was to determine the effectiveness of N-acetylcysteine (NAC) and ethyl pyruvate in preventing ischemia-reperfusion injury.
Method
This study is a randomized, controlled experimental study. In group 1, rats' left
main carotid arteries were clamped. Reperfusion was established by releasing the clamp
after 1.5 hours. In group 2, the left main carotid artery was clamped, and 20 mg/kg
intraperitoneal NAC was administered after 1 hour. The clamp was released 0.5 hour
after NAC administration. In group 3, rats' left carotid arteries were clamped, and
50 mg/kg ethyl pyruvate was administered intraperitoneally after 1 hour. The clamp
was released 0.5 hour after ethyl pyruvate administration. All tissue samples were
collected 2.5 hours after reperfusion. Brain tissues were compared histopathologically.
Results
A higher percentage of degenerative neurons was determined in group 1 compared with
groups 2 and 3 (P values: Pa = .003 and Pc = .003, respectively). A significant difference was also observed between groups
2 and 3 (Pb = .003), with the percentage of degenerative neurons being lower in the NAC group
than in the ethyl pyruvate group.
Conclusion
The use of NAC and ethyl pyruvate reduces injury resulting from ischemia-reperfusion
in an experimental animal model of acute ischemic stroke and subsequent reperfusion.
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Article Info
Publication History
Published online: June 05, 2016
Accepted:
June 2,
2016
Received in revised form:
May 31,
2016
Received:
March 28,
2016
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
