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Elevated cardiac biomarkers are not associated with mortality in low-risk cardiac patients with severe sepsis

      Previous research has shown that cardiac dysfunction in severe sepsis worsens outcomes and increases mortality [
      • Klouche K
      • Pommet S
      • Amigues L
      • Bargnoux AS
      • Dupuy AM
      • Machado S
      • et al.
      Plasma brain natriuretic peptide and troponin levels in severe sepsis and septic shock: relationships with systolic myocardial dysfunction and intensive care unit mortality.
      ]. Dogan et al. [
      • Biteker FS
      • Doğan V
      • Başaran Ö
      • Biteker M
      Predictors of Mortality in Severe Sepsis.
      ] in their correspondence point out that further evidence is still necessary to prove that elevated cardiac biomarkers, specifically cardiac troponin I (cTnI) and brain natriuretic (BNP) levels, are associated with higher mortality for patients with severe sepsis. As requested, we conducted an analysis using the same study sample that was used to evaluate the Mortality in Severe Sepsis in the Emergency Department scoring method, which identified several clinical factors associated with higher in-hospital mortality [
      • McCormack D
      • Ruderman A
      • Menges W
      • Kulkarni M
      • Murano T
      • Keller SE
      Usefulness of the Mortality in Severe Sepsis In The Emergency Department score in an urban tertiary care hospital.
      ]. For statistical analysis, the Student t test was used to determine an association between cardiac biomarkers, ejection fraction (EF%), and in-hospital mortality.
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      References

        • Klouche K
        • Pommet S
        • Amigues L
        • Bargnoux AS
        • Dupuy AM
        • Machado S
        • et al.
        Plasma brain natriuretic peptide and troponin levels in severe sepsis and septic shock: relationships with systolic myocardial dysfunction and intensive care unit mortality.
        J Intensive Care Med. 2014; 29: 229-237
        • Biteker FS
        • Doğan V
        • Başaran Ö
        • Biteker M
        Predictors of Mortality in Severe Sepsis.
        2016 ([in press])
        • McCormack D
        • Ruderman A
        • Menges W
        • Kulkarni M
        • Murano T
        • Keller SE
        Usefulness of the Mortality in Severe Sepsis In The Emergency Department score in an urban tertiary care hospital.
        Am J Emerg Med. 2016; 34: 1117-1120