Abstract
Purpose
Copeptin, the C-terminal portion of provasopressin, has emerged as a novel prognostic
marker in neurocritical care, such as in traumatic brain injury (TBI). The aim of
this study was to quantitatively assess the prognostic significance of initial plasma
copeptin levels in the neurological outcome and mortality after traumatic brain injury.
Materials and methods
Six relevant studies with data from 552 patients were included in this meta-analysis.
Results
The plasma copeptin levels were found to be significantly higher in patients who died
than in the survivors (standardized mean difference [SMD], 1.80). In the four studies
reporting Glasgow outcome scale (GOS) data, patients with unfavorable outcomes had
significantly higher copeptin levels than those with favorable outcomes (SMD, 1.62).
The plasma copeptin level predicted mortality and unfavorable outcomes (AUC, 0.873;
AUC, 0.876).
Conclusions
The present meta-analysis suggests that early measurement of plasma copeptin levels
can provide better prognostic information about the functional outcome and mortality
in patients with TBI.
Keywords
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Article Info
Publication History
Published online: April 19, 2017
Accepted:
April 18,
2017
Received in revised form:
April 17,
2017
Received:
December 1,
2016
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
