Abstract
Background
Ureter muscles contraction movements caused pain in renal colic. Magnesium sulphate
could influence the pain by reducing acetylcholine in the nerve terminals. We have
aimed to evaluate the analgesic effects of magnesium sulphate on acute renal colic
pain.
Method
In this double-blind clinical trial study, the patients with renal colic pain were
randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg
of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml
normal plus 30 mg of Ketorolac. The pain severity of patients was assessed using the
visual analog scale (VAS) at baseline, and 15 and 30 min after intervention.
Results
Baseline pain score and demographic characteristics did not significantly different
between the groups. After 30 min the pain score significantly reduced in both groups.
While, at 15 and 30 min, mean pain score did not show statistically significant differences.
Conclusion
Our findings indicated that Magnesium sulphate did not influence renal colic pain
relief.
Keywords
To read this article in full you will need to make a payment
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of Emergency MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diagnostic management of renal colic.Radiologia. Apr 30 2015; 57 ([English Edition]): 113-122
- Therapeutic approaches for renal colic in the emergency department: a review article.Anesth Pain Med. Feb 2014; 4
- Prevalence and risk factors of kidney stone.Global J Res Anal. 2016; 5
- Adult urolithiasis in a population-based study in Iran: prevalence, incidence, and associated risk factors.Urol Res. Apr 1 2007; 35: 73-82
- Pathophysiology of reno-ureteral colic.Urol Int. 2004; 72: 20-23
- Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial.Emerg Med J. Jan 1 2011; 29: 5-902
- Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial.Lancet. May 20 2016; 387: 1999-2007
- The role of non-steroidal anti-inflammatory drugs in renal colic.Pharmaceuticals. Apr 28 2010; 3: 1304-1310
- Effect of intra-operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery.Anaesthesia. Feb 1 2003; 58: 131-135
- Intravenous magnesium sulfate for post-operative pain in patients undergoing lower limb orthopedic surgery.Acta Anaesthesiol Scand. Sep 1 2009; 53: 1088-1091
- Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery.Br J Anaesth. Nov 25 2005; 96: 247-252
- Pharmacokinetics of ketorolac loaded to polyethylcyanoacrylate nanoparticles using UPLC MS/MS for its determination in rats.Int J Pharm. Sep 15 2010; 397: 173-178
- Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects.Am J Gastroenterol. Jan 1 2002; 97: 65-71
- The effect of magnesium sulfate on renal colic pain relief; a randomized clinical trial.Emergency. 2017; 5
- Analgesic effect of perineural magnesium sulphate for sciatic nerve block for diabetic toe amputation: a randomized trial.PLoS One. May 2 2017; 12e0176589
- Intravenous infusion of magnesium sulfate and postoperative analgesia in total knee arthroplasty.Minerva Anestesiol. Nov 2015; 81: 1184-1191
- Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.Acta Cir Bras. Jan 2016; 31: 67-73
Article Info
Publication History
Published online: August 24, 2018
Accepted:
August 16,
2018
Received:
August 2,
2018
Footnotes
☆IRCT clinical trial registry: (IRCT: IRCT2016050125027N2), http://www.irct.ir.
☆☆Ethic code: (IR.AJUMS.REC.1395.458).
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
