In recent years, the number of patients intoxicated with caffeine, a xanthine derivative
(1,3,7-trimethylxanthine), has increased in Japan, and severe or fatal cases have
been reported [
[1]
]. Theophylline is another xanthine derivative (1,3-dimethylxanthine) that shares
a similar pharmacokinetic profile with caffeine. For the treatment of severe theophylline
poisoning, hemodialysis (HD) is the preferred recommended extracorporeal treatment,
whereas charcoal hemoperfusion (CHP) is acceptable if HD is not available [
[2]
]. Thus, these hemopurification methods may also be recommended for treating severe
caffeine poisoning. However, no studies have addressed whether HD or CHP is superior
for treating severe caffeine poisoning through an assessment of caffeine clearance
(CL). Here we discuss two cases of severe caffeine poisoning; one patient was treated
by HD and the other by CHP.Keywords
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References
- A retrospective study on the epidemiological and clinical features of emergency patients with large or massive consumption of caffeinated supplements or energy drinks in Japan.Intern Med. 2018; 57: 2141-2146
- EXTRIP workgroup. Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup.Clin Toxicol. 2015; 53: 215-229
- Drug levels: therapeutic and toxic serum/plasma concentrations of common drugs.J Clin Monit. 1999; 15: 529-544
- Removal of doripenem during hemodialysis and the optimum dosing regimen for patients undergoing hemodialysis.Ther Apher Dial. 2011; 15: 327-333
- Pharmacokinetic considerations in clinical toxicology: clinical applications.Clin Pharmacokinet. 2007; 46: 897-939
Article Info
Publication History
Published online: March 08, 2019
Accepted:
March 8,
2019
Received in revised form:
March 6,
2019
Received:
December 19,
2018
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
