Abstract
Background
Sertraline showed some potential in alleviating depressive disorder after traumatic
brain injury. This systematic review and meta-analysis was conducted to investigate
the efficacy of sertraline on the treatment of depressive disorder after traumatic
brain injury.
Methods
The databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library
databases were systematically searched for collecting the randomized controlled trials
(RCTs) regarding the efficacy of sertraline for traumatic brain injury.
Results
This meta-analysis included five RCTs. The initial use of sertraline was within 8 weeks
after traumatic brain injury. Compared with control group for traumatic brain injury,
sertraline treatment showed no significant improvement on Hamilton Depression Rating
Scale (HAM-D) (standard mean difference (Std. MD) = −0.08; 95% confidence interval
(CI) = −0.45 to 0.28; P = 0.65), anxiety score (Std. MD = 0.08; 95% CI = −0.32 to
0.48; P = 0.69), aggression score (Std. MD = −0.12; 95% CI = -0.56 to 0.32; P = 0.59),
or quality of life (QOL) score (Std. MD = −0.06; 95% CI = −0.49 to 0.37; P = 0.78).
There was no statistical difference of diarrhea (risk ratio (RR) = 0.85; 95% CI = 0.92
to 3.71; P = 0.08), dizziness (RR = 1.15; 95% CI = 0.57 to 2.31; P = 0.70), dry mouth
(RR = 2.44; 95% CI = 0.43 to 13.89; P = 0.32), nausea or vomiting (RR = 1.17; 95%
CI = 0.37 to 3.70; P = 0.79) between sertraline group and control group.
Conclusions
Sertraline showed no obvious benefits for the relief of depressive disorder after
traumatic brain injury.
Keywords
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Article Info
Publication History
Published online: June 29, 2019
Accepted:
June 28,
2019
Received in revised form:
June 22,
2019
Received:
March 25,
2019
Identification
Copyright
© 2019 Published by Elsevier Inc.
