Rhabdomyolysis induced acute kidney injury (AKI) develops due to leakage of the potentially
nephrotoxic intracellular content into the circulation. This study aimed to evaluate
the prevalence and predictive factors of AKI in Kermanshah earthquake victims.
This cross-sectional study was performed on victims of 2017 Kermanshah earthquake,
Iran, who were admitted in Kermanshah and Tehran Hospitals. Data of the hospitalized
patients were gathered and the prevalence of rhabdomyolysis induced AKI was studied.
In addition, correlations of various clinical and laboratory variables with rhabdomyolysis
induced AKI were assessed.
370 hospitalized patients with the mean age of 39.24 ± 20.32 years were studied (58.6%
female). 10 (2.7% of all admitted) patients were diagnosed with AKI. Time under the
rubble (p < .0001), serum level of creatinine phosphokinase (CPK) (p < .001), lactate dehydrogenase (LDH) (p < .0001), aspartate aminotransferase (AST)
(p = .001) and uric acid (p = .003) were significantly higher in patients with AKI. Area under the ROC curves
of CPK, LDH, AST, and uric acid for predicting the risk of developing AKI were 0.883
(95% CI: 0.816–0.950), 0.865 (95% CI: 0.758–0.972), 0.846 (95% CI: 0.758–0.935), and
0.947 (95% CI: 0.894–0.100), respectively. The best cutoff points for CPK, LDH, AST,
and uric acid in this regard were 1656 IU/L, 839.5 U/L, 46.00 IU/L, and 5.95 mg/dL.
The rate of traumatic rhabdomyolysis induced AKI development was estimated to be 2.7%.
Time under the rubble and serum levels of CPK, LDH, AST, and uric acid were identified
as the most important predictive factors of AKI development.