Highlights
- •The incidence of atrial fibrillation (AF) in sepsis varied with different conditions.
- •Patients with sepsis-related new-onset AF had prolonged ICU and hospital stays.
- •New-onset AF was correlated with increased mortality, stroke risk and recurrence of AF.
Abstract
Background
The outcomes of new-onset atrial fibrillation (AF) during sepsis are inconsistent
and inconclusive. This meta-analysis aims to provide a comprehensive description of
the impact of new-onset AF on the prognosis of sepsis.
Methods
Three electronic databases (PubMed, Embase, and the Cochrane Library) were searched
for relevant studies. Meta-analysis was performed using odds ratios (OR) and 95% confidence
intervals (CI) as effect measures.
Results
A total of 225,841 patients from 13 individual studies were incorporated to the meta-analysis.
The summary results revealed that new-onset AF during sepsis was associated with increased
odds of in-hospital mortality (pooled OR: 2.09; 95% CI: 1.53–2.86; p < 001), post-discharge mortality (pooled OR: 2.44; 95% CI: 1.81–3.29; p < .001), and stroke (pooled OR:1.88; 95% CI: 1.13–3.14; p < .05). Results also indicated that the incidence of new-onset AF varied from 1.9%
for mild sepsis to 46.0% for septic shock. Furthermore, compared to those without
AF, people with new-onset AF had longer ICU and hospital stays, as well as a higher
recurrence of AF.
Conclusions
New-onset AF is frequently associated with adverse outcomes in patients with sepsis.
This is a clinical issue that warrants more attention and should be managed appropriately
to prevent poor prognosis.
Keywords
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Article Info
Publication History
Published online: January 04, 2021
Accepted:
December 20,
2020
Received in revised form:
December 15,
2020
Received:
October 18,
2020
Identification
Copyright
© 2020 Published by Elsevier Inc.
