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Efficacy and safety of tranexamic acid in pediatric trauma patients: Evidence from meta-analysis

Published:February 08, 2021DOI:https://doi.org/10.1016/j.ajem.2021.02.009
      Trauma requiring massive transfusions hinders the successful resuscitation and deteriorates outcomes [
      • Safiejko K.
      • Smereka J.
      • Filipiak K.J.
      • et al.
      Effectiveness and safety of hypotension fluid resuscitation in traumatic hemorrhagic shock: a systematic review and meta-analysis of randomized controlled trials.
      ]. Antifibrinolytic therapy has become an emerging standard in the resuscitation of patients in early hemorrhagic shock and should be administered as soon as potentially lethal hemorrhage is suspected [
      • Morrison J.J.
      • Dubose J.J.
      • Rasmussen T.E.
      • Midwinter M.J.
      Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study.
      ]. Tranexamic acid (TXA) inhibits plasminogen activation.

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