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Abstract
Presently, there is no reliable noninvasive method of assessing the adequacy of cardiopulmonary
resuscitation (CPR). Studies of animals have shown that during prolonged arrest the
coronary perfusion pressure (CPP) is correlated with successful resuscitation. During
previous studies it appeared that expired PCO2 correlated with CPP. To investigate this relationship, eight mongrel dogs (mean weight,
22.7 ± 5.8 kg) were anesthetized with pentobarbitol. Catheters were placed in the
thoracic aorta and right atrium of each dog. Each animal was electrically fibrillated,
and CPR was started using mechanical resuscitator. The PCO2 was determined at end expiration using a Hewlett Packard 47210A Capnometer with the
electrode attached to the endotracheal tube. After 10, 15, 20, or 25 minutes of ventricular
fibrillation and closed-chest massage, a thoracotomy was performed, and internal massage
was begun. Coronary perfusion pressure was calculated at least each minute and correlated
with the PCO2 values. A correlation coefficient of 0.78 was calculated based on 368 data points
for eight dogs (P < 0.01). The results of this study indicate that expired PCO2 is positively correlated with CPP in the canine model of CPR. Inasmuch as CPP correlates
with survival in prolonged CPR, the noninvasive measurement of PCO2 may be a useful method of assessing the adequacy of CPR.
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Article Info
Publication History
Accepted:
November 9,
1984
Received:
November 2,
1981
Footnotes
☆Supported by a grant-in-aid from the American Heart Association, Arizona Affiliate.
☆☆Presented at the Fifth Purdue Conference on CPR and Defibrillation, West Lafayette, Indiana, September 25–26, 1984.
Identification
Copyright
© 1985 Published by Elsevier Inc.
