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Abstract
Dextromethorphan, a common ingredient in cough syrups, has rarely been described to
cause toxicity. The authors describe an unusual case of a known asthmatic presenting
with somnolence, who appeared to be in end-stage respiratory failure. Her partial
response to routine naloxone, 1 mg, was surprising. However, additional naloxone was
required to completely normallze the patient's mental status. The authors suggest
naloxone be administered in doses of 0.4 mg or more intravenously in suspected dextromethorphan
overdose.
Keywords
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References
- Dextromethorphan danger.N Engl J Med. 1986; 314: 993
- Toxic psychosis due to dextromethorphan.Med J Aust. 1967; 2: 231
- Fatal intoxication by dextromethorphan: A report on two cases.Forensic Sci Intl. 1988; 37: 233-236
- Determination of dextromethorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans.J Pharm Sci. 1977; 66: 1047-1048
- Moffat AC Jackson JV Moss MJ Clarke's isolation and identification of Drugs. Pharmaceutical Press, London, England1986: 521
- Action of narcotics on pupil.Anesthesia. 1987; 42: 566
- Dextromethorphan toxicity: Reversal by naloxone.Pediatrics. 1977; 59: 117-119
- ed 4. Poisindex. Vol 61. Micromedix, Inc, Denver, CO1989
Article Info
Publication History
Accepted:
November 10,
1990
Received:
January 9,
1990
Footnotes
☆Presented at The American Academy of Clinical Toxicology Annual Meeting, Atlanta, GA.
Identification
Copyright
© 1991 Published by Elsevier Inc.