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Acute isopropanol ingestion: Pharmacokinetic parameters in the infant

  • K.Michael Parker
    Correspondence
    Address reprint requests to Dr Parker, Toxicology Laboratory, Oklahoma Medical Center, PO Box 26307, Oklahoma City, OK 73126.
    Affiliations
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
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  • Thomas A. Lera Jr
    Affiliations
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
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      Abstract

      We describe a case of isopropanol intoxication in a 2-month-old infant. The source of isopropanol and both the route and time of ingestion could be clearly identified. Serial measurements of isopropanol and acetone provided data for calculating their respective elimination half-lives. Isopropanol (half-life = 5.8 hr) clearance was similar to values reported for adults; acetone (half-life = 10.8 hr) was eliminated twice as rapidly as in adults.

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