Abstract
Objectives
Ischemia-modified albumin (IMA) is an emerging diagnostic biomarker for many ischemic
conditions. This study was conducted to investigate whether there is a change in IMA
levels in carbon monoxide (CO) poisoning and, if so, the clinical relevance of IMA
levels.
Methods
This cohort study, performed between November 2008 and April 2009, compared the serum
IMA levels of 33 CO-poisoned patients taken at the time of presentation at the emergency
department and after 3 hours of treatment and 49 healthy controls. In addition, IMA
and carboxyhemoglobin levels were analyzed according to CO poisoning patients' poisoning
severity scores.
Results
Carbon monoxide patients' IMA levels were higher than those of the control group both
at time of admission and at the third hour of the treatment, P < .0001. A significant fall was determined in carboxyhemoglobin (CO-Hb) levels at
the end of the third hour of treatment, P < .0001. However, there was no significant difference between the IMA levels measured
at admission and at the end of the third hour of treatment (P > .05). There was no significant correlation between IMA and CO-Hb levels in CO-poisoned
patients. Also, there was no difference in blood IMA levels in classification according
to patients' poisoning severity score and CO-Hb levels.
Conclusion
Results from this pioneering study established a high level of IMA in CO-poisoned
patients, suggesting that IMA may also be sensitive to hypoxia. Considering the preliminary
nature of this study, the clinical utility of IMA levels in CO poisoning should be
further investigated with more comprehensive studies.
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Article Info
Publication History
Published online: May 03, 2010
Accepted:
February 3,
2010
Received in revised form:
January 12,
2010
Received:
December 1,
2009
Footnotes
☆We declare that we have no financial interest or conflict of interest with anybody or organizations in relation to the data presented in this study.
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
