Abstract
Background
Intravenous lipid emulsion eliminates the toxicity-related symptoms of several drugs.
We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated
rats.
Methods
Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats
received digoxin infusion at a rate of 12 mL/h (0.25 mg/mL). Five minutes after the
start of digoxin infusion, animals were treated either with 12.4 mL/kg intravenous
lipid emulsion (group L) or saline (group C). The primary outcome variable was time
elapsed until asystole development. Cumulative dose of digoxin required to induce
asystole was also recorded.
Results
Mean time until asystole development in groups C and L were 21.28 ± 8.61 and 32.00
± 5.41 minutes, respectively (P< .05). The mean lethal doses of digoxin in the groups C and L were 3.97 ± 1.54 and
6.09 ± 0.96 mg/kg, respectively (P< .05).
Conclusion
Intravenous lipid emulsion prolonged the time until asystole development and increased
cumulative lethal dose in rats intoxicated with digoxin.
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Article Info
Publication History
Published online: March 17, 2016
Accepted:
March 14,
2016
Received:
February 17,
2016
Footnotes
☆Financial support: none.
☆☆Conflict of interest: none.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
