It was with great interest that I read the article “Optimal dosing of intravenous
ketamine for procedural sedation in children in the ED—a randomized controlled trial,”
published by Kannikeswaran et al
[
[1]
] in the April issue of The American Journal of Emergency Medicine. In this article, 125 children were randomized on a convenience sample to receive
1, 1.5, or 2.0 mg/kg of intravenous (IV) ketamine for procedural sedation. The authors
found that an adequate sedation was achieved with all doses of ketamine and that higher
doses did not increase the risk of adverse events; besides, 1.5 or 2.0 mg/kg required
less redosing and better physician satisfaction after the procedure.- Kannikeswaran N
- Lieh-Lai M
- Malian M
- Wang B
- Farooqi A
- Roback MG
Optimal dosing of intravenous ketamine for procedural sedation in children in the
ED—a randomized controlled trial.
Am J Emerg Med. 2016; ([pii: S0735–6757(16)30011–0])https://doi.org/10.1016/j.ajem.2016.03.064
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References
- Optimal dosing of intravenous ketamine for procedural sedation in children in the ED—a randomized controlled trial.Am J Emerg Med. 2016; ([pii: S0735–6757(16)30011–0])https://doi.org/10.1016/j.ajem.2016.03.064
- Clinical practice guideline for emergency department ketamine dissociative sedation in children.Ann Emerg Med. 2004; 44: 460-471
- Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update.Ann Emerg Med. 2011; 57: 449-461
- Serious adverse events during procedural sedation with ketamine.Pediatr Emerg Care. 2009; 25: 325-328
- A retrospective comparison of ketamine dosing regimens for pediatric procedural sedation.Eur J Emerg Med. 2015; 22: 111-116
- A fixed-dose ketamine protocol for adolescent sedations in a pediatric emergency department.J Pediatr. 2014; 165: 453-458
- Ketamine may be related to reduced ejection fraction in children during the procedural sedation.Hum Exp Toxicol. 2016; ([pii: 0960327116637112, Epub ahead of print])
Article Info
Publication History
Published online: June 29, 2016
Accepted:
June 21,
2016
Received:
June 21,
2016
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
