Abstract
Introduction
The purpose of our study is to evaluate the efficacy of penta-therapy for HL-SAP in
a retrospective study.
Methods
Retrospective study between January 2007 and December 2016 in a hospital intensive
care unit. HL-SAP patients were assigned to conventional treatment alone (the control
group) or conventional treatment with the experimental protocol (the penta-therapy
group) consists of blood purification, antihyperlipidemic agents, low-molecular weight
heparin, insulin, covering the whole abdomen with Pixiao (a traditional Chinese medicine).
Serum triglyceride, serum calcium, APACHE II score, SOFA score, Ranson score, and
other serum biomarkers were evaluated. The hospital length of stay, local complications,
systematic complications, rate of recurrence, overall mortality, and operation rate
were considered clinical outcomes.
Results
63 HL-SAP patients received conventional treatment alone (the control group) and 25
patients underwent penta- therapy combined with conventional treatment (the penta-therapy
group). Serum amylase, serum triglyceride, white blood cell count, C-reactive protein,
and blood sugar were significantly reduced, while serum calcium was significantly
increased with penta-therapy. The changes in serum amylase, serum calcium were significantly
different between the penta-therapy and control group on 7th day after the initiation
of treatment. The reduction in serum triglyceride in the penta-therapy group on the
second day and 7th day were greater than the control group. Patients in the penta-therapy
group had a significantly shorter length of hospital stay.
Conclusion
This study suggests that the addition of penta-therapy to conventional treatment for
HL-SAP may be superior to conventional treatment alone for improvement of serum biomarkers
and clinical outcomes.
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Article Info
Publication History
Published online: February 03, 2018
Accepted:
January 30,
2018
Received in revised form:
January 29,
2018
Received:
October 26,
2017
Footnotes
☆This project was supported by a grant from the Important and weak subject construction project of Shanghai Health and Family Planning System (No.: 2016ZB0205).
Identification
Copyright
© 2018 Published by Elsevier Inc.
