Use of a mucosal atomization device for local application of tranexamic acid in epistaxis

Published:April 18, 2018DOI:
      Epistaxis is a very common condition in the general population with an estimated 60% of the total population of the United States experiencing at least one episode of epistaxis throughout their life. In most of the cases epistaxis results from a rupture of a vessel in the anterior area of the nose and may be treated with direct pressure [
      • Tabassom A.
      • Cho J.J.
      Epistaxis (nose bleed).


      To read this article in full you will need to make a payment
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Emergency Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Tabassom A.
        • Cho J.J.
        Epistaxis (nose bleed).
        StatPearls Publishing, 2017 ([Accessed November 14, 2017])
        • Koudounarakis E.
        • Chatzakis N.
        • Papadakis I.
        • Panagiotaki I.
        • Velegrakis G.
        Nasal packing aspiration in a patient with Alzheimer's disease: a rare complication.
        Int J Gen Med. 2012; 5: 643-645
        • Rotenberg B.
        • Tam S.
        Respiratory complications from nasal packing: systematic review.
        J Otolaryngol Head Neck Surg. 2010; 39 ([Accessed December 6, 2017]): 606-614
        • Shakur H.
        • Roberts I.
        • Bautista R.
        • Caballero J.
        • Coats T.
        • Dewan Y.
        • et al.
        Eff ects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with signifi cant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
        Lancet. 2010; 376: 23-32
        • Abrams J.
        Die lokale Anwendung von Tranexamsäure in der HNO-Chirurgie.
        HNO. 2012; 60: 1014-1018
        • Traboulsi H.
        • Alam E.
        • Hadi U.
        Changing trends in the management of epistaxis.
        Int J Otolaryngol. 2015; 2015263987
        • Klepfish A.
        • Berrebi A.
        • Schattner A.
        Intranasal tranexamic acid treatment for severe epistaxis in hereditary hemorrhagic telangiectasia.
        Arch Intern Med. 2001; 161 ([Accessed November 14, 2017]): 767
        • Zahed R.
        • Moharamzadeh P.
        • AlizadehArasi S.
        • Ghasemi A.
        • Saeedi M.
        A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial.
        Am J Emerg Med. 2013; 31: 1389-1392
        • Zahed R.
        • Mousavi Jazayeri M.H.
        • Naderi A.
        • Naderpour Z.
        • Saeedi M.
        Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial.
        Acad Emerg Med. November 2017;
        • Tibbelin A.
        • Aust R.
        • Bende M.
        • et al.
        Effect of local tranexamic acid gel in the treatment of epistaxis.
        ORL J Otorhinolaryngol Relat Spec. 2017; 57 (Accessed November 14): 207-209
        • Rech M.A.
        • Barbas B.
        • Chaney W.
        • Greenhalgh E.
        • Turck C.
        When to pick the nose: out-of-hospital and emergency department intranasal administration of medications.
        Ann Emerg Med. 2017; 70: 203-211