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Comments on Shenfu injection for improving cellular immunity and clinical outcome in patients with sepsis or septic shock

  • Hairong Cai
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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  • Zicong Zhao
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
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  • Shuling Liu
    Affiliations
    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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  • Huanjia Gao
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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  • Jieqin Zhuang
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
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  • Yanhong Chen
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
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  • Weizhang Zhang
    Affiliations
    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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  • Shuai Zhao
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
    Search for articles by this author
  • Bojun Chen
    Correspondence
    Corresponding author at: NO. 55, Neihuan Xi Road, University Town, Panyu District, Guangzhou City, Guangdong Province, China.
    Affiliations
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

    Department of Emergency, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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Published:November 20, 2018DOI:https://doi.org/10.1016/j.ajem.2018.11.030
      We read with interest the article by Ning Zhang et al. [
      • Zhang N.
      • Liu J.
      • Qiu Z.
      • et al.
      Shenfu injection for improving cellular immunity and clinical outcome in patients with sepsis or septic shock.
      ]. The author conducted a prospective, random, controlled trials (RCTs) to compare the clinical effects and safety of Shenfu injection (SFI) in patients with sepsis or septic shock, which found that SFI should improve cellular immunity but not clinical outcome. We congratulate the authors for this successful article, however, some issues should be discussed to avoid misinterpretations.

      Abbreviations:

      SFI (Shenfu injection), RCTs (random, controlled trials)

      Keywords

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