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Nebulized tranexamic acid for post-tonsillectomy hemorrhage in children: a promising game changer

Published:January 29, 2020DOI:https://doi.org/10.1016/j.ajem.2020.01.042
      Hemorrhage after tonsillectomy can be a life-threatening condition in the pediatric population [
      • Francis D.O.
      • Fonnesbeck C.
      • Sathe N.
      • McPheeters M.
      • Krishnaswami S.
      • Chinnadurai S.
      Postoperative bleeding and associated utilization following tonsillectomy in children: a systematic review and meta-analysis.
      ]. Several interventions have been used to prevent and treat this life-threatening bleeding; however, in cases of severe hemorrhage, most of them are not effective in controlling bleeding and this could put a lot of stress on emergency physicians and nurses. Therefore, due to the high risk of postoperative hemorrhage, it is still necessary to discover fast-acting and efficacious treatments.
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      References

        • Francis D.O.
        • Fonnesbeck C.
        • Sathe N.
        • McPheeters M.
        • Krishnaswami S.
        • Chinnadurai S.
        Postoperative bleeding and associated utilization following tonsillectomy in children: a systematic review and meta-analysis.
        156(3). 2017: 442-455
        • Pabinger I.
        • Fries D.
        • Schöchl H.
        • Streif W.
        • Toller W.
        Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis.
        Wien Klin Wochenschr. 2017; 129: 303-316
        • Karkouti K.
        • Ho L.T.S.
        Preventing and managing catastrophic bleeding during extracorporeal circulation.
        Hematology Am Soc Hematol Educ Program. 2018; 2018: 522-529
        • Zhang Y.
        • Liu H.
        • He F.
        • Chen A.
        • Yang H.
        • Pi B.
        Does tranexamic acid improve bleeding, transfusion, and hemoglobin level in patients undergoing multi-level spine surgery? A systematic review and meta-analysis.
        World Neurosurg. 2019; 127: 289-301
        • Song G.
        • Yang P.
        • Zhu S.
        • Luo E.
        • Feng G.
        • Hu J.
        • et al.
        Tranexamic acid reducing blood transfusion in children undergoing craniosynostosis surgery.
        J Craniofac Surg. 2013; 24: 299-303
        • Komura S.
        • Rodriguez R.M.
        • Peabody C.R.
        Hemoptysis? Try inhaled tranexamic acid.
        J Emerg Med. 2018; 54 (e97-e9)
        • Bafaqih H.
        • Chehab M.
        • Almohaimeed S.
        • Thabet F.
        • Alhejaily A.
        • AlShahrani M.
        • et al.
        Pilot trial of a novel two-step therapy protocol using nebulized tranexamic acid and recombinant factor VIIa in children with intractable diffuse alveolar hemorrhage.
        Ann Saudi Med. 2015; 35: 231-239
        • Schwarz W.
        • Ruttan T.
        • Bundick K.
        Nebulized tranexamic acid use for pediatric secondary post-tonsillectomy hemorrhage.
        Ann Emerg Med. 2019; 73: 269-271