Abstract
Introduction
The efficacy of ginger for migraine remains controversial. We conduct a systematic
review and meta-analysis to explore the influence of ginger versus placebo on treatment
in migraine patients.
Methods
We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases
through September 2020 for randomized controlled trials (RCTs) assessing the effect
of ginger versus placebo on treatment efficacy in migraine patients. This meta-analysis
is performed using the random-effect model.
Results
Three RCTs are included in the meta-analysis. Overall, compared with control group
in migraine patients, ginger treatment is associated with substantially improved pain
free at 2 h (RR = 1.79; 95% CI = 1.04–3.09; P = 0.04) and reduced pain scores at 2 h (MD = −1.27; 95% CI = −1.46 to −1.07; P < 0.00001), but reveals no obvious impact on treatment response (RR = 2.04; 95% CI = 0.35–11.94;
P = 0.43) or total adverse events (RR = 0.80; 95% CI = 0.46–1.41; P = 0.44). The incidence of nausea and vomiting is obviously lower in ginger group
than that in control group.
Conclusions
Ginger is safe and effective in treating migraine patients with pain outcomes assessed
at 2 h.
Keywords
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Article Info
Publication History
Published online: November 17, 2020
Accepted:
November 14,
2020
Received in revised form:
November 4,
2020
Received:
October 18,
2020
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2020 Published by Elsevier Inc.