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Safety of push-dose phenylephrine in adult ICU patients

      Vasopressor medications are used to increase blood pressure in hypotensive, intensive care unit (ICU) patients. Typically, vasopressors are administered as continuous intravenous (IV) infusions. Due to the quick onset and short half-life of vasopressor medications, these infusions are able to be quickly titrated to a target blood pressure. However, the administration of continuous infusions can be delayed because of the time required to compound and deliver the medications. Recent evidence even suggests that infusion dead space can delay medication administration by several minutes [
      • Gregerson B.G.
      • Larsen A.L.
      • Kelly S.M.
      • et al.
      Effect of intravenous infusion dead space on time to drug delivery in infants.
      ]. Greater duration of hypotension has been associated with increased risk of mortality, acute kidney injury, and myocardial injury in adult ICU patients [
      • Maheshwari K.
      • Nathanson B.H.
      • Munson S.H.
      • et al.
      The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients.
      ].
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